38. Early stages of hyaline membrane disease

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Prevention of Hyaline Membrane Disease

The high mortality of respiratory distress syndrome in premature infants and the relative ineffectiveness of treatment' make two recent reports of special interest. They are clinical studies2 3 which attempt to clarify the role of corticosteroids in prevention and treatment. New forms of treatment for this puzzling disorder have sometimes been introduced without adequate trials, so that it is h...

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Biochemical basis of hyaline membrane disease.

Pulmonary function in a normal fetus is dependent upon maturation and maintenance of the biochemical synthesis of a distinct surface-active lipid. Two major pathways for the biosynthesis of this major surface-active lipid, dipalmitoyl lecithin, are described and relative activities of each pathway in human lung are discussed. In normal human lung, the CDP-choline path­ way is quantitatively mos...

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Hyaline membrane disease. II. Lung lecithin.

Boughton, K., Gandy, G., and Gairdner, D. (1970). Archives of Disease in Childhood, 45, 311. Hyaline membrane disease. H: Lung lecithin. The lecithin content of lung, together with its surface tension properties, were determined in 34 stillbirths, and 61 neonatal deaths. Lecithin content ranged widely from 1-5 to 18 6% of dry lung tissue. In 24 cases the 'palmitic-lecithin' was also measured; i...

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Assisted Ventilation in Terminal Hyaline Membrane Disease.

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Hyaline membrane disease. I. Cellular changes.

numerous granules usually indicated normal surfactant and their absence a lack. It is concluded that the granules represent surfactant material. Osmiophilic granules were found first at 20 weeks' gestation (in 2 out of 6 fetuses). After 24 weeks' gestation almost all infants had many granules, except those with HMD. The earliest stages in hyaline membrane formation consisted of interstitial oed...

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ژورنال

عنوان ژورنال: Pediatric Research

سال: 1971

ISSN: 0031-3998,1530-0447

DOI: 10.1203/00006450-197102000-00043